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“We note five key limitations of our study. First, our sample suffers from the selection Nope Pi Day Funny Face Mask Teacher Student Shirt, since participants were self-selected from a microdosing workshop. As a result, most of our participants had tried psychedelics previously, which means that they may have broken blind easier or may have been desensitized to the microdosing effects. Second, the psilocybin doses were made by the participants using dried psilocybin truffles, meaning that we cannot be sure of the exact amounts of psilocybin in the individual doses that the participant’s Nope Pi Day Funny Face Mask Teacher Student Shirt. It is possible that the degree of psilocybin content varied across participants and thereby obscured our results. Third, we encountered a large drop-out rate during this project and several participants did not sufficiently comply with the behavioral guidelines to be included in the analyses. My understanding was that periodic full doses were much more effective, especially when paired with more traditional therapy. It’s news to me that anyone was looking into the effects of microdosing, especially an antidepressant. This resulted in a small sample size relative to existent observational studies and in a further selection bias (i.e. only motivated participants likely stayed in). Moreover, due to such sample size, our study may have been underpowered to detect true effects, particularly the interaction effect hypothesized for the emotional go/no-go task.

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Our post hoc power analysis suggested that our design, given our observed Nope Pi Day Funny Face Mask Teacher Student Shirt, was insufficiently powered to detect this effect. Simulated data in the hypothesized direction, however, yielded sufficient power with a large effect size. Of course, as noted earlier, this analysis based on simulated data remains speculative and we encourage future studies to plan their sample size according to expected RT patterns. Fourth, we measured the effects in our study only after self-administration of a dose, and not This Is My Official Napping Orangutan Lover Gift Shirt doses or after each block. Thus, our results may be confounded by the acute effect of the psilocybin dose, which may differ from its persistent effect after the acute chemical-induced symptoms have subsided. However, Szigeti et al. (2021) did assess both acute and post-acute effects and found no significant microdose vs placebo differences in psychological outcomes when accounting for participants breaking blind. Last, our study is a combined field and lab-based study, meaning that the results may not be readily generalizable or replicable, for example, in a more clinical setting.”

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